Apollo 15, the fourth manned lunar landing, was launched on July 26, 1971, atop a Saturn V rocket. The crewmembers were Commander David Scott, Command Module Pilot Alfred Worden, and Lunar Module Pilot James Irwin. Command and Service Modules 112, "Endeavour," docked with the Lunar Module "Falcon" after launch. Following a routine trans-lunar flight and entry into lunar orbit, Scott and Irwin climbed into "Falcon", separated from the Command Module and landed at Hadley Ridge on the moon. During their time on the lunar surface, they traversed a total of 27.9 km of lunar terrain and collected nearly 77 kg of lunar samples, using a Lunar Roving Vehicle for the first time. After almost 67 hours on the lunar surface, Scott and Irwin returned to the "Endeavour" for an uneventful trip back to Earth where they landed in the Pacific Ocean on August 7. The crew was the first crew for which post-flight quarantine was not required.

"Endeavour" was placed on display by NASA at the U.S. Air Force Museum in Ohio in December 1973. Ownership was transferred to the National Air and Space Museum in July 1974.