The powerful GR-2600 engine series was developed from experience with the earlier R-1510 and R-1670 models. Design of the Wright Cyclone 14 began in late-1935, with the first run in late-1936, and certification in mid-1937. Using 115-grade fuel in a high-compression version, the Cyclone 14 made transatlantic passenger service practical when an order was placed by Pan American Airways, Inc. for twenty five to be installed in the new Boeing Model 314 Clipper Ships.

Along with the Boeing 314, the GR-2600-A2A powered other commercial aircraft such as the Brewster 340, Douglas DB7A and DB7B, Short Brothers Stirling, Vultee 72, Martin M-1878-1, and Boeing SA-307B. A total of 8,821 commercial GR-2600 engines of all models were built between May 1937 and January 1946. A total of 76,488 military GR-2600 engines of all models were built between February 1937 and April 1945, and powered such aircraft as the North American B-25, Martin PMB Mariner, and Vultee A-31.